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toromus

Tacrolimus is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.

Composition

Tacrolimus Capsules 0.5 mg &1 mg

Mode of Action

Tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.

Indications

Tacrolimus is indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants

Dosage

1. Patient Population -> Adult Kidney transplant in combination with azathioprine / Recommended Initial Oral Dosage (two divided doses every 12 hours) -> 0.2 mg/kg/day / Observed Whole Blood Trough Concentrations -> month 1-3: 7-20 ng/mL, month 4-12: 5-15 ng/mL, 2. Patient Population -> In combination with MMF/IL-2 receptor antagonist / Recommended Initial Oral Dosage (two divided doses every 12 hours) -> 0.1 mg/kg/day / Observed Whole Blood Trough Concentrations -> month 1-12: 4-11 ng/mL

This information is for the registered medical practitioners only. Consult your medical practitioner before consuming the products.