mycotor-s-360
Mycotor S 360, Mycophenolic acid Tablets USP 360 is an immunosuppressant used to prevent organ transplant rejections. It is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. It was derived from Penicillium stoloniferum, and has also shown antibacterial, antifungal and antiviral properties. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. This regimen can be used in place of the older anti-proliferative azathioprine due to its stronger immunosuppressive potency. Mycotor S 360 is available as enteric-coated tablets of delayed-release, in an effort to improve upper gastrointestinal adverse events by delaying mycophenolic acid release until it reaches the small intestine.
Composition
Mycophenolic acid Tablets USP 360 mg
Mode of Action
Mycophenolic acid is a selective non-competitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), that blocks that blocks de novo biosynthesis of purine nucleotides (conversion of inosine-5-phosphate and xanthine-5-phosphate to guanosine- 5-phosphate). This affects lymphocytes primarily and leads to the suppression of DNA synthesis in T- and B-cells. Mycophenolic acid arrests the T-lymphocyte cell cycle at the G1/S interface and inhibits the proliferation of lymphocytes. Mycophenolic acid also suppresses antibody formation by B-lymphocytes and prevents the glycosylation of lymphocyte and monocyte glycoproteins involved in intercellular adhesion to endothelial cells.
Indications
Mycophenolic acid is an antimetabolite immunosuppressant indicated for prophylaxis of organ rejection in adult patients receiving kidney transplants and in pediatric patients at least 5 years of age and older who are at least 6 months post kidney transplant.
Dosage
1. Adults : 720 mg orally, twice daily (1,440 mg total daily dose) on an empty stomach, 1 hour before or 2 hours after food intake, 2. Pediatric : 5 years of age and older (who are at least 6 months post kidney transplant), 400 mg/m 2 body surface area orally, twice daily (up to a maximum of 720 mg twice daily), 3. Do not crush, chew, or cut tablet prior to ingestion.
This information is for the registered medical practitioners only. Consult your medical practitioner before consuming the products.